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KMID : 0895820120220010011
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Journal of Oriental Rehabilitation Medicine
2012 Volume.22 No. 1 p.11 ~ p.22
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Anti-fatigue Effect of Fermented Deer Velvet Antler Extract in Sprague-Dawley Rats
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Chung Won-Seok
Kim Sung-Su
Oh Jae-Gueun
Lee Jun-Hwan
Kim Koh-Woon
Jo Yoong-Ki
Yeon Chang-Ho
Lee Jong-Soo
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Abstract
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Objectives :The aim of this study was to investigate the Anti-muscle fatigue effect of fermented deer velvet antler extract in Sprague-Dawley rats.
Methods : Rats were randomly divided into four groups of 10 mice each according to a randomized block design. Saline solution was orally administered to the control group, 100 mg/kg of water-extract of deer velvet antler to the positive control group, 50 mg/kg of fermented deer velvet antler extract to experimental group 1 and 100 mg/kg of fermented deer velvet antler extract to experimental group 2. Each of the four groups were treated for seven days and then participated in a forced swimming test which applied both a high intensity exercise model and a prolonged exercise model. We observed swimming times and examined blood biochemical parameters.
Results : In the high intensity exercise model, the effect of the deer velvet antler was seen in the increased swimming times. Experimental group 2 swam for approximately 600% longer as compared to the control group(p<0.001), indicating that the recovery effect is dose-dependent. In the forced swimming tests using the prolonged exercise model, blood sugar levels(p<0.001) and free fatty acid levels(p<0.05, p<0.01 each) in the positive control group and experimental groups 1 and 2 demonstrated a significant recovery effect in comparison with the control group.
Conclusions : Fermented deer velvet antler extract may have an Anti-muscle fatigue effect similar to that of deer velvet antler extract and could be used when it has an effect equal to one-fifth of the amount considering the yield rate.
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KEYWORD
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Deer Antler, Fermentation, Anti-muscle fatigue effect, Oriental medicine
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